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酵母基因用于Tyr-DNA基化酶,该基因修复了topoisomerase I复合体

J J Pouliot1, K C Yao, C A Robertson

  • 1Laboratory of Molecular Biology, National Institute of Mental Health, Building 36, Room 1B08, Bethesda, MD 20892-4034, USA.

Science (New York, N.Y.)
|October 16, 1999
PubMed
概括

研究人员确定了一种酶的基因,该酶可以分解有毒的拓酶I-DNA复合体. 缺乏这种酶的酵母突变体对DNA损伤敏感,这表明它们有修复作用. 这一发现影响了癌症化疗策略.

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