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通过SnoNcoprotein对TGF-β信号的负反调节

S L Stroschein1, W Wang, S Zhou

  • 1Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall, Mail Code 3206, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|October 26, 1999
PubMed
概括

通过与Smad蛋白相互作用,SnoN基蛋白抑制了转化生长因子-β (TGF-β) 信号传递. TGF-β刺激最初会降解SnoN,使基因激活,但后来会增加SnoN以终止信号传输.

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