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Updated: Jul 23, 2026

Measuring Single-Cell Mitochondrial DNA Copy Number and Heteroplasmy Using Digital Droplet Polymerase Chain Reaction
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Measuring Single-Cell Mitochondrial DNA Copy Number and Heteroplasmy Using Digital Droplet Polymerase Chain Reaction

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在人类mtDNA的复制控制区域中,依赖于衰老的大规模积累点突变,用于复制

Y Michikawa1, F Mazzucchelli, N Bresolin

  • 1Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

Science (New York, N.Y.)
|October 26, 1999
PubMed
概括

线粒体DNA (mtDNA) 突变随着年龄的增长而累积,特别是在特定的复制控制区域. 这些与年龄相关的mtDNA变化在生命的晚期出现,并且可以在细胞内广泛传播.

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