慢性阻塞性肺病中心肺动脉病变:一项跨食道心声学研究
1Department of Cardiology, Ospedale Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo, Italy.
Circulation
|October 27, 1999
概括
中央肺动脉 (CPA) 病变在慢性阻塞性肺病 (COPD) 患者中很常见,即使没有肺栓塞. 这些病变,通常是动脉样硬化,似乎与COPD的严重程度无关.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
背景情况:
- 经食道回声心脏图 (TEE) 通常在急性肺栓塞中识别中央肺动脉 (CPA) 病变,这种病变归因于血栓塞或动脉样硬化.
- 在一次性肺高血压中,CPA病变与局部血栓形成或动脉样硬化有关.
- 这项研究研究了慢性阻塞性肺病 (COPD) 患者没有肺栓塞的CPA病变.
研究的目的:
- 为了确定COPD患者中CPA病变的患病率和特征.
- 为了区分COPD中的CPA病变与通常在肺栓塞中看到的病变.
- 探索CPA病变与COPD严重程度或肺高血压之间的关系.
主要方法:
- 经食道心声学 (TEE) 用于检查25名COPD患者和27名对照人群.
- 之前患有肺栓塞或深静脉血栓症的患者被排除在外.
- CPA病变被分类,发现与CT/MR血管学和临床数据相关联.
主要成果:
- 中心肺动脉 (CPA) 病变在48%的COPD患者中被检测到,而对照组的7.4% (P<0.01).
- 暗示动脉样硬化的壁粘性 (类型2) 病变在COPD患者中 (36%) 比对照患者 (3.7%) 显著更常见 (P<0.01).
- 在有或没有CPA病变的COPD患者之间没有观察到肺功能或血液动力学的显著差异,尽管病变存在与更大的肺动脉尺寸相关.
结论:
- 经食道心声学 (TEE) 在稳定的慢性阻塞性肺病 (COPD) 患者中经常显示中央肺动脉 (CPA) 病变.
- 这些病变即使没有显著的肺高血压也会发生.
- 在COPD中CPA病变的存在和特征似乎与肺功能障碍的严重程度没有密切联系.
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