显著的机制促进了Arabidopsis的带中的极性建立
Y Eshed1, S F Baum, J L Bowman
1Section of Plant Biology, University of California, Davis 95616, USA.
Cell
|October 27, 1999
概括
植物器官不对称性涉及YABBY基因家族. 龙爪和GYMNOS基因共同工作,龙爪控制空间转录,而GYMNOS控制时间差异化,以便适当的骨发育.
科学领域:
- 植物发育生物学植物发育生物学
- 分子遗传学 分子遗传学
- 基因调节 基因调节
背景情况:
- 植物侧面器官表现出不对称性,由阿拉比多普西斯YABBY基因家族决定的轴性身份.
- 爪 (CRC) 是一个关键的YABBY基因家族成员,参与建立极性.
- 之前的研究表明,CRC和其他基因 (如GYMNOS (GYM) 和KANADI (KAN)) 之间存在潜在的冗余.
研究的目的:
- 调查爪和健身房在植物器官极性和骨发育中的精确作用.
- 为了澄清基因相互作用和基因底层的调节机制的基因相互作用和调节机制.
- 区分功能冗余和在骨分化中的不同的调节作用.
主要方法:
- 在Arabidopsis的CRABS CLAW,GYMNOS和KANADI基因中发生突变的分析.
- 在突变系中观察子宫外附带性骨组织的形成.
- 基因相互作用研究,以评估突变的综合影响.
主要成果:
- 仅仅在的突变并没有导致极分化的丧失.
- 宫外状骨组织仅在爪功能与GYMNOS或KANADI一起受到损害时才形成.
- GYMNOS是染色体重塑蛋白Mi2的同类蛋白,其表达均.
结论:
- 龙爪和体育馆并不是通过简单的分子冗余作用.
- 的爪子在空间上调节基因转录,而GYMNOS则在时间上调节下游的目标.
- 这种由CRABS CLAW和GYMNOS协调的空间和时间调节对于适当的骨分化和植物器官极性至关重要.
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