在塞拉菲尔德核再加工厂的男性辐射工人的后代中死产
L Parker1, M S Pearce, H O Dickinson
1Department of Child Health, University of Newcastle upon Tyne, UK. Louise.Parker@ncl.ac.uk
Lancet (London, England)
|October 30, 1999
概括
在塞拉菲尔德,父亲对电离辐射的暴露与死亡出生风险的增加有关. 核工人的这一发现表明潜在的跨代效应,与动物研究一致,但风险估计较高.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 辐射流行病学 辐射流行病学
背景情况:
- 电离辐射是一种已知的变异原体,人类跨代数据有限.
- 塞拉菲尔德核电站的工人受到高职业辐射暴露.
- 这项研究调查了塞拉菲尔德工人孩子的父亲辐射暴露和死产风险.
研究的目的:
- 为了确定父亲对电离辐射的暴露是否与死产的风险增加有关.
- 量化父亲的怀孕前辐射剂量与死产风险之间的关联.
主要方法:
- 在坎布里亚州 (1950-1989) 分析了248,097名活产儿和3,715名死产儿的出生登记数据.
- 鉴定了130名死产婴儿和9078名活产婴儿,这些婴儿是塞拉菲尔德男性辐射工人的伴侣.
- 对社会阶级,出生年份,父亲的年龄和出生顺序进行了调整后勤回归分析.
主要成果:
- 父亲产前辐射暴露与死产风险之间存在显著的积极关联 (OR每100mSv:1.24).
- 观察到与先天异常,特别是神经管缺陷的死胎的风险增加.
- 模型表明,130例中0-31.9例死胎可能归因于父亲的辐射暴露.
结论:
- 生死胎风险增加与父亲的职业辐射暴露相关,与动物模型保持一致.
- 在人类中观察到的风险估计比动物研究中更高.
- 统计分析证实了模型匹配,没有证据表明未测量的混因素.
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