病理性疼痛的皮层起源于皮层
1Department of Physiology, University of Otago Medical School, Dunedin, New Zealand. john.harris@stonebow.otago.ac.nz
Lancet (London, England)
|October 30, 1999
概括
幻肢疼痛和重复性应变损伤可能源于大脑.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 发动机控制器 发动机控制器
背景情况:
- 没有明显组织损伤的疼痛,就像幻肢疼痛一样,是一个长期存在的医学难题.
- 最近的发现强调了与感官和运动信号不匹配相关的大脑活动.
- 诸如重复性应变损伤和焦点手 dystonias 这样的条件涉及大脑的感觉运动皮质的变化.
研究的目的:
- 在没有直接组织损伤的情况下,探索潜在的疼痛感知神经机制.
- 调查感觉运动皮层和自身感知代表在病理性疼痛中的作用.
- 为了在不同类型的疼痛和感官不匹配条件之间进行并行.
主要方法:
- 关于皮质活动的最新神经科学发现的综述.
- 分析涉及感觉运动皮层可塑性和疼痛的情况.
- 疼痛机制与感官冲突现象 (如运动恶心) 的比较.
主要成果:
- 一个特定的皮质区域被运动意图,运动意识和视觉反之间的不一致激活.
- 感觉运动皮质的塑性变化与幻肢感觉和重复性应变损伤有关.
- 无组织的自感皮质表现可以通过信号虚假的运动感官不匹配,导致病理性疼痛.
结论:
- 病理性疼痛,包括幻肢疼痛和重复性应变损伤,可能源于感官信息的皮质处理失调.
- 感官反的不一致,特别是在感官运动系统内,是产生疼痛的关键因素.
- 了解这些大脑机制可能为治疗疼痛疾病提供新的途径,而无需清晰的组织病理.
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