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Updated: Jul 16, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

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Published on: September 7, 2017

DNA甲基转移酶Dnmt3a和Dnmt3b对于新甲基化和哺乳动物发育至关重要

M Okano1, D W Bell, D A Haber

  • 1Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA.

Cell
|November 11, 1999
PubMed
概括

两个DNA甲基转移酶Dnmt3a和Dnmt3b对于在发育过程中建立新的DNA甲基化模式至关重要. 它们的无活化停止了de novo甲基化,影响了小鼠的发育,并可能导致ICF综合征等疾病.

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