相关实验视频
Updated: Jul 14, 2026

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Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
Published on: December 1, 2015
在绵羊中,伴膜环状扩张和无伴膜吐的乳头肌肉脱
G R Green1, P Dagum, J R Glasson
1Department of Cardiovascular and Thoracic Surgery, Stanford University School of Medicine, California 94305-5247, USA.
Circulation
|November 24, 1999
概括
不对称的额头环状扩张单独不会导致功能性额头环状反 (MR). 七侧环状扩张,以及间接变化和乳头肌肉位移,对于MR的发展是必要的.
科学领域:
- 心血管研究的心血管研究.
- 心脏机械学心脏机械学
- 中心门疾病的疾病.
背景情况:
- 功能性甲骨管反 (MR) 与不对称的甲骨管环状 (MA) 扩张和乳头肌肉脱位有关.
- 了解MR的几何机制对于开发有效的治疗方法至关重要.
研究的目的:
- 为了研究导致功能性MR的 mitra annulus 和 papillary 肌肉中的特定几何变化.
- 在MR病原发生过程中区分intercommissural和septolateral环状尺寸的作用.
主要方法:
- 在绵羊心脏中植入放射性斑点标记器,以跟踪MA和乳头肌肉运动.
- 创建了一个实验小组,使用醇诱导前环状和叶片肌肉消灭.
- 利用双平面视频光学和血液动力学记录来分析心脏几何和功能.
主要成果:
- 与对照组相比,在实验组中,心肌环状区域增加了11-13% .
- 这一增长主要是由于交叉轴的延长,其中一个案例显示了双轴扩大.
- 在实验小组中,前面的乳头肌肉尖端偏向了心交环和前侧左心室.
结论:
- 交心环状扩张在间接维度和前侧乳头肌肉位移不足以引起MR.
- 功能性MR的发展可能需要在七侧轴中进行状环状扩张,可能模仿冠状动脉封闭的影响.
相关概念视频
Enlargement of the Plasma Membrane
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
Cell Motility through Blebbing
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
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Blebbing Through the Matrix
In multicellular...
Types of Membrane Protrusions
The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
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The microvilli, an example of stable protrusions, are finger-like projections with a...
Papillary Dermis
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
The Mammary Glands
The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...

