在非抽冠状动脉旁路手术期间,人类的区域左心室缩功能
P M Brown1, V B Kim, B J Boyer
1Department of Surgery, Division of Cardiothoracic Surgery, East Carolina University School of Medicine, Greenville, NC 27858, USA.
Circulation
|November 24, 1999
概括
带有局部阻塞的非抽动冠状动脉旁路移植 (CABG) 会导致暂时的心肌缺血,影响静脉功能. 然而,在再输血后,功能完全恢复,这表明没有永久性损伤,但在特定的患者群体中具有潜在的临床意义.
科学领域:
- 心血管外科心血管外科
- 心脏生理学 心脏生理学
- 心肌缺血的研究研究心肌缺血.
背景情况:
- 通过使用局部冠状动脉封闭,在非抽冠状动脉旁路移植 (CABG) 期间研究心肌缺血的临床意义.
- 评估暂时局部冠状动脉封闭对心脏手术患者区域性静脉功能的影响.
研究的目的:
- 为了确定临时局部冠状动脉封闭在非 CABG 期间对区域性静脉功能的影响.
- 评估心肌缺血的程度和在CABG程序的背景下,在局部阻塞后的恢复.
主要方法:
- 在接受CABG的8名患者中使用了压力导管和超声波尺寸传感器.
- 测量区域性缩功能 (百分比缩缩短) 和压力维度环在左前下降动脉局部阻塞之前,期间和之后.
- 分析了冠状动脉狭窄程度与细分缩短的变化之间的相关性.
主要成果:
- 局部冠状动脉封闭导致最大静脉缩短显著下降 (从5.8%降至1.8%).
- 在恢复血液流动后,心肌功能完全恢复到基线水平,没有透缩变的证据.
- 观察到冠状动脉狭窄程度与细分缩短的减少之间存在显著的逆相关性.
结论:
- 在CABG期间,暂时局部冠状动脉封闭会导致暂时的心肌功能障碍,但不会造成永久性损伤.
- 在再注血后,功能完全恢复,这表明缺血的短暂性质.
- 这些缺血变化的临床意义可能在患有不太严重的冠状动脉狭窄症的患者中更大.
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