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不统一的直接心脏压缩的生理和血液动力学评估
J H Artrip1, G H Yi, H R Levin
1Department of Surgery, Division of Cardiothoracic Surgery, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Circulation
|November 24, 1999
概括
双心室直接心脏压缩 (DCC) 通过改善心室压力和增加心脏输出来增强心脏功能. 这种新的方法可以避免与接触血液的室腔辅助装置相关的并发症.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 心脏衰竭研究研究
背景情况:
- 目前的心室辅助器件由于血液/器件接口而带来风险.
- 双直心压缩 (DCC) 为心脏支持提供了一个无血的替代方案.
- 一个经过临床设计的DCC装置被开发用于同步心脏压缩.
研究的目的:
- 评估一种新型双心室直心压缩 (DCC) 装置的疗效.
- 在失败的心脏模型中评估DCC对心脏功能的影响.
- 为了确定DCC是否可以减轻现有的心室支系统的并发症.
主要方法:
- 以计算机化后载系统进行ex vivo狗心脏准备.
- 通过冠状动脉栓塞诱导的急性缺血性心力衰竭的体内狗模型.
- 在各种心室预负荷和模拟心力衰竭条件下测试DCC.
主要成果:
- DCC将末缩压力-体积关系向上转移了大约40%的压缩压力.
- 在严重的心力衰竭中,DCC将心脏输出 (CO) 增加了104%,平均动脉压增加了95%.
- 氧化碳恢复到正常基线值的60%左右,显示出显著的血液动力学改善.
结论:
- 不均的DCC显著增强左和右心室压力产生.
- 在急性心力衰竭中,DCC有效地增加心脏输出量和平均动脉压.
- DCC设备提供了一个有希望的替代方案,有可能避免血液/设备接口并发症.
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