在市内公共住房的儿童中接种乙型肝炎疫苗,1991-1997年
D S Lauderdale1, R J Oram, K P Goldstein
1Department of Health Studies, University of Chicago, Ill 60637, USA. lauderdale@health.bsd.uchicago.edu
JAMA
|November 24, 1999
概括
在城市人口中,乙型肝炎疫苗 (HBV) 覆盖率达到50%. 早期的HBV免疫改善了其他儿童疫苗的及时接种,可能会增加整体疫苗接种率.
科学领域:
- 儿童传染病 儿童传染病
- 公共卫生和流行病学.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 1991年推对婴儿进行普遍的乙型肝炎病毒 (HBV) 疫苗接种.
- 建议在出生后几天内启动HBV疫苗系列.
研究的目的:
- 评估低收入城市人口的HBV疫苗覆盖率.
- 调查早期的HBV免疫是否会影响随后的疫苗接种.
主要方法:
- 一项使用儿童免疫计划免疫记录的队列研究.
- 对1143名1991-1997年间出生于芝加哥公共住房开发区的儿童进行分析,随访时间为35个月.
- 及时接收HBV疫苗剂量,DTP剂量1和4:3:1系列的评估.
主要成果:
- 按时接种HBV疫苗的覆盖率在1995年或之后出生的婴儿中停滞在50%左右.
- 在第一个月内接受首次HBV剂量的儿童,获得DTP剂量1及时的可能性显著增加 (60.1%与36.4%相比).
- 早期的HBV免疫与完成HBV系列和4:3:1系列在19个月后的更高率有关.
结论:
- 在这个城市人口中,HBV疫苗的接种率在推的三年内达到与其他疫苗相当的水平.
- 婴儿在出生时接种HBV疫苗与及时接种其他必要的儿童疫苗有关.
- 早期的HBV免疫可能会提高早期儿童疫苗接种计划遵守率较低的人群中疫苗接种完成率.
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