在阻塞性睡眠呼吸暂停中,夜间连续的正气道压力降低了白天的同情性流量
K Narkiewicz1, M Kato, B G Phillips
1Department of Internal Medicine, University of Iowa, Iowa City, USA.
Circulation
|December 11, 1999
概括
持续的正气道压力 (CPAP) 在阻塞性睡眠呼吸暂停 (OSA) 患者中显著降低了肌肉交感神经活动 (MSNA). 对OSA进行CPAP治疗的这种有益效果在治疗六个月和一年后观察到.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 神经学 神经学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 的特征是肌肉交感神经活动 (MSNA) 的升高.
- 在OSA患者中高MSNA有助于心血管并发症.
研究的目的:
- 调查长期连续正气道压力 (CPAP) 治疗对OSS患者MSNA的影响.
- 为了确定CPAP治疗是否可以使OSA中交感神经活动升高的正常化.
主要方法:
- 一项涉及11名接受CPAP治疗的正常压力OSA患者和9名未接受治疗的OSA患者的研究.
- 血压,心率和MSNA的测量是在基线,1个月,6个月和1年进行的.
- 对CPAP治疗组和未治疗对照组之间的MSNA变化进行比较.
主要成果:
- 在治疗和未治疗的OSA患者中,血压和心率在一年内保持不变.
- 肌肉交感神经活动 (MSNA) 在未经治疗的OSA组中没有显著变化.
- 在CPAP治疗6个月和1年后,在OSA患者中观察到MSNA显著下降 (P=0.02).
结论:
- 持续的正气道压力 (CPAP) 有效地降低了阻塞性睡眠呼吸暂停 (OSA) 患者的肌肉交感神经活动.
- 在OSA中,CPAP的交感抑制作用需要延长治疗时间,在六个月后变得明显,持续长达一年.
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