在皮层神经网络中同步刺的稳定传播
M Diesmann1, M O Gewaltig, A Aertsen
1Department of Neurobiology and Biophysics, Institute of Biology III, Albert-Ludwigs-University, Frieburg, Germany.
Nature
|December 11, 1999
概括
神经网络可以使用精确的尖峰时间传输信息,挑战传统的速率编码观点. 这项研究在皮质网络模型中展示了同步的动作潜力,使得毫秒级的神经通信成为可能.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 经典观点认为神经信息是由神经元发射率编码的.
- 神经编码中精确的尖峰定时因假定的神经噪声和有限的保真性而受到质疑.
- 突触输入波动被认为阻碍了毫秒级信号传输.
研究的目的:
- 在一个现实的网络模型中,研究神经编码中精确的尖峰定时的可行性.
- 为了确定同步的动作潜能是否可以在模仿皮质活动的系统中传播.
- 探索基于单尖协调的组合神经代码的潜力.
主要方法:
- 开发一个皮层网络活动的计算模型.
- 模拟神经动力学以评估尖峰时间精度.
- 通过吸引力动态控制的网络同步的分析.
主要成果:
- 精确同步的动作潜能被证明在模型网络中传播.
- 该模型回顾了生物神经系统的关键特征.
- 吸引力动力学被确定为次毫秒尖峰精度的机制.
结论:
- 精确的尖峰时间是皮层状网络中神经编码的可行机制.
- 由吸引器控制的网络同步,支持毫秒忠实度.
- 理论上,使用单尖协调的组合神经代码是可能的.
相关概念视频
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Action Potential: Phases of Stimulation
The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Propagation of Action Potentials
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Neural Circuits
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...


