在成功的沙静脉移植干预后,肌酸激酶-MB酶的升高与晚期死亡率有关
1Cardiovascular Research Foundation, Washington Hospital Center, Washington, DC, USA.
Circulation
|December 14, 1999
概括
在软静脉移植 (SVG) 干预后主要肌酸激酶-MB (CK-MB) 的升高预测了更高的长期死亡率. 即使没有其他并发症,这种风险仍然存在,强调CK-MB作为关键的预后标志物.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 生物标志物 生物标志物
背景情况:
- 沙芬静脉移植 (SVG) 干预具有较高的肌酸激酶-MB (CK-MB) 升高的风险.
- 在SVG干预后周边过程性CK-MB升高的预后价值尚未得到充分确立.
研究的目的:
- 研究SVG血管成形术成功后,围手术CK-MB升高对晚期临床事件的影响.
主要方法:
- 分析了成功进行SVG干预的1056名患者的队列.
- 根据CK-MB水平,患者被分为几组:正常,小幅上升 (1-5倍正常) 和重大上升 (>5倍正常).
- 临床事件和死亡率在30天和1年的随访期被评估.
主要成果:
- 在CK-MB组之间没有观察到30天主要临床事件的显著差异.
- 与正常 (4.8%) 相比,轻微 (6.5%) 和重大 (11.7%) CK-MB升高的患者的一年死亡率显着更高.
- 主要CK-MB升高是晚期死亡率 (OR 3.3) 的最强的独立预测因素,其次是糖尿病.
结论:
- 主要CK-MB升高发生在15%的成功SVG干预中.
- 术周CK-MB升高与SVG血管造形术后晚期死亡率的增加显著相关.
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