对于内皮粘附分子的新型调节器:来自脂肪细胞的血蛋白 adiponectin
1Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan. ouchi@imed2.med.osaka-u.ac.jp
Circulation
|December 22, 1999
概括
发现肥胖症下降的蛋白质阿迪波内克可以减少血管细胞的炎症. 患者体内的较低皮素水平表明,它可能有助于评估冠状动脉疾病风险.
科学领域:
- 内分泌学 在内分泌学.
- 心血管生物学 心血管生物学
- 分子医学是分子医学.
背景情况:
- 肥胖与心血管疾病有关,但潜在的机制尚不清楚.
- 阿迪波涅丁是一种由脂肪细胞分泌的因子,被发现在肥胖中减少.
- 阿迪波涅丁在内皮功能和冠状动脉疾病 (CAD) 中的作用需要进一步研究.
研究的目的:
- 为了研究阿迪波内克丁对内皮细胞功能的影响.
- 为了确定血腺素水平和冠状动脉疾病之间的关系.
主要方法:
- 试验室内:人类大动脉内皮细胞 (HAEC) 用阿迪波内克丁和瘤坏死因子-α (TNF-α) 进行治疗.
- 评估了THP-1细胞对HAEC的粘附性和VCAM-1,E-selectin和ICAM-1的表达.
- 在体内:在患有CAD的患者和对照者中,使用ELISA测量了血腺素度.
主要成果:
- 阿迪波涅克丁抑制了THP-1细胞对HAECs的TNF-α诱导的粘附.
- 亚迪波内克丁剂量依赖性降低了HAEC上VCAM-1,E-selectin和ICAM-1的表达.
- 与对照组相比,冠状动脉疾病患者的血腺素水平显著降低.
结论:
- 阿迪波涅丁调节了内皮的炎症反应.
- 血腺素水平可以作为评估冠状动脉疾病风险的生物标志物.
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