CD46是人类疹病毒6的细胞受体
F Santoro1, P E Kennedy, G Locatelli
1Unit of Human Virology, DIBIT, San Raffaele Scientific Institute, Milano, Italy.
Cell
|January 5, 2000
概括
人类疹病毒6 (HHV-6) 使用人类CD46作为其感染和细胞融合的细胞受体. 这一发现为HHV-6提供了新的见解.
科学领域:
- 病毒学和免疫学 病毒学和免疫学
- 细胞生物学 细胞生物学
背景情况:
- 人类疹病毒6 (HHV-6) 与exanthema subitum,免疫功能低下个体的机会性感染,多发性硬化症和艾滋病进展有关.
- 了解HHV-6的细胞受体对于阐明其病原和热带性至关重要.
研究的目的:
- 确定人类疹病毒6 (HHV-6 A和B) 的两个主要亚组使用的细胞受体.
- 研究这种受体在HHV-6感染,细胞融合和致病性中的作用.
主要方法:
- 实验涉及评估HHV-6与人类细胞的相互作用.
- 单克隆抗体和可溶性CD46用于阻止HHV-6介导的感染和细胞融合.
- 重组人类CD46在非人类细胞中得到表达,以测试对HHV-6的敏感性.
主要成果:
- 两个HHV-6亚组A和B都被证明使用人类CD46作为它们的细胞受体.
- 表面CD46表达在HHV-6感染期间下降.
- 单克隆抗体和可溶性CD46特别抑制了HHV-6感染和细胞融合;表达CD46的非人类细胞对HHV-6变得敏感.
结论:
- 人类CD46作为人类疹病毒6 (HHV-6) 亚组A和B的细胞受体.
- HHV-6利用无处不在的免疫调节受体,为病毒热带性和病原性提供了新的视角.
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