维生素C对手腕骨折中反射交感性的频率的影响:一项随机试验
P E Zollinger1, W E Tuinebreijer, R W Kreis
1Department of Orthopaedics, Leyenburg Hospital, The Hague, The Netherlands.
Lancet (London, England)
|January 15, 2000
概括
补充维生素C显著降低了手腕骨折后反射交感性缩症 (RSD) 的风险. 这种抗氧化剂可能有助于预防类似损伤的创伤后缩.
科学领域:
- 整形外科手术 整形外科手术
- 创伤学 创伤学 创伤学
- 临床药理学 临床药理学
背景情况:
- 反射交感性缩症 (RSD) 的发病因和治疗仍然不清楚.
- 高发病率,医疗费用,以及与创伤后缩症相关的工作缺席需要预防策略.
- 由于有毒氧基的潜在作用,研究了维生素C (酸) 作为预防性抗氧化剂.
研究的目的:
- 为了评估维生素C作为预防性剂对创伤后反射交感性损伤 (RSD) 的疗效,在保守治疗手腕骨折后.
主要方法:
- 一个前性,双盲,随机试验,涉及123名127名手腕骨折的成年人.
- 参与者每天接受500毫克维生素C或安慰剂,持续50天.
- 对RSD的临床评分和随访是在1年内进行的.
主要成果:
- 在维生素C组的手腕中,RSD发生在7%的手腕中,而在安慰剂组的22% (15%的差异).
- 补充维生素C与显著降低RSD的风险有关.
- 与造和骨折类型的投诉也是RSD发生的显著预后变量.
结论:
- 维生素C的预防与手腕骨折后反射交感性损的风险降低有关.
- 这些发现表明,维生素C在预防创伤后丧症方面可能发挥有益作用.
- 这种预防作用可能扩展到其他形式的创伤.
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