血管新素转化酶基因中的插入/删除多态影响心脏体重
K Nakahara1, S Matsushita, H Matsuoka
1Department of Laboratory Medicine, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan. nakahara@tmig.or.jp
Circulation
|January 19, 2000
概括
ангиотензин转化酶 (ACE) 基因型影响心脏体重,DD基因型显示显著更高的心脏质量. 然而,高血压和年龄等因素是心脏重量的更强有力的预测因素.
科学领域:
- 心血管遗传学 心血管遗传学
- 分子心脏病学分子心脏病学
- 高血压研究 高血压研究
背景情况:
- ангиотензин II (Ang II) 调节左心室质量,其由 ACE 生产与 ACE 基因插入/删除 (I/D) 多态相关.
- 由于ACE多态的Ang II度的变化可能会影响左心室质量.
研究的目的:
- 为了调查ACE基因型是否预测尸检患者的心脏重量.
主要方法:
- 分析了443名患者的尸检数据,不包括患有特定心脏病的患者.
- 通过对脏DNA的聚合酶链反应确定ACE基因型.
- 对身体表面积的心脏重量进行校正.
主要成果:
- 与ID (230.0±51.2 g/m2) 和II (226.8±49.8 g/m2) 基因型相比,DD基因型组 (249.9±49.9 g/m2) 的心脏重量显著更高.
- 心脏重量与年龄和冠状动脉狭窄指数正相关.
- 高血压史,年龄和DD基因型被确定为心脏体重的独立预测因素.
结论:
- ACE基因型是心脏质量的预测指标.
- 发现高血压和年龄比ACE基因型更有力地预测心脏质量.
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