维拉帕米尔对长期高心率诱导的心房电力改造的影响
1Shin Kong Wu Ho-Su Memorial Hospital, National Yang-Ming University, Taiwan, ROC.
Circulation
|January 19, 2000
概括
维拉帕米尔并没有阻止狗的长期电动重塑从心动减速. 这种药物还增加了心房动 (AF) 的持续时间,无论是在节拍之前还是之后.
科学领域:
- 心血管电生理学 心血管电生理学
- 药理学 药理学 是一个学科.
背景情况:
- 维拉帕米尔对高心率诱导的心房电力改造的长期影响仍未得到研究.
- 心房重塑是心房动 (AF) 病理生理学的关键因素.
研究的目的:
- 在狗模型中,调查维拉帕米尔在快速心房节奏期间和之后对心房电生理性质的影响.
- 为了确定维拉帕米尔是否可以预防或减轻心动节拍引起的心房电力改造.
主要方法:
- 48只狗被随机分配到维拉帕米尔和对照组.
- 在1天,1周或6周快速心房节奏之前和之后评估了心房有效耐火期 (AERP),AF诱导性和AF持续时间.
- 维拉帕米尔每天给120毫克的维拉帕米尔组.
主要成果:
- 维拉帕米尔减弱的AERP缩短,分散,适应不良和AF诱导能力在1天的节奏后.
- 这些保护作用在1周或6周的节奏后没有观察到.
- 维拉帕米尔在节拍前显著延长了AF持续时间,并在1周和6周节拍后增加了AF持续时间.
结论:
- 维拉帕米尔并不能预防长期的心动力衰竭引起的心房电生理变化.
- 在持续的快速心房节奏的背景下,维拉帕米尔会加剧AF持续时间.
- 这些发现表明,在患有心房动或有心房动风险的患者使用维拉帕米尔时,应谨慎使用.
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