相关实验视频
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Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
在VDJ重组的发育调节中,胰岛素乙化的作用
1Department of Immunology, Post Office Box 3010, Duke University Medical Center, Durham NC 27710, USA.
概括
素乙化调节了V(D) J重组的可访问性. 增强剂活性驱动长距离的素H3过乙化,这对于发育过程中的V(D) J重组是必不可少的.
科学领域:
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- V(D) J重组是适应性免疫的一个关键过程,在发育过程中由增强剂元素调节.
- 增强剂控制重组信号序列可访问性的精确分子机制在很大程度上是未知的.
研究的目的:
- 为了研究基因组修饰的作用,特别是基因组H3乙化,在调节V(D) J重组的作用.
- 为了确定增强剂活性是否会影响激素乙化和再组合部位的可访问性.
主要方法:
- 测量跨记者结构和内源性T细胞受体α/delta locus. histone H3乙化水平.
- 对增强剂活性,基因素乙化状态和V(D) J重组效率之间的相关性进行分析.
主要成果:
- 增强剂活性诱导了长期的,发育调节的素H3乙化变化.
- 发现素H3乙化水平与V(D) J重组密切相关.
- 在与增强剂驱动的可访问性相结合时,观察到素H3的过度乙化.
结论:
- 希斯H3过乙化被提出为关键的分子机制,将增强剂活性与染色质可访问性联系起来.
- 这种表观遗传修饰促进了重组酶进入V(D) J重组的重组信号序列.
- 这些发现提供了对免疫受体基因组合的发育调节的洞察.
相关概念视频
Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Hormonal Regulation
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Stomach pH Regulation
The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
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Hormones Regulating Blood Glucose
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In addition to accelerating glucose uptake and utilization, insulin has...
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Regulation of the Digestive System
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The effectors in this regulation system are glands and smooth muscles. Activation of these...
The effectors in this regulation system are glands and smooth muscles. Activation of these...
Hormones Secreted by the Stomach
Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:

