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Updated: May 1, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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通过分子适配器Cbl-bb对淋巴细胞激活和自身免疫的负调节

K Bachmaier1, C Krawczyk, I Kozieradzki

  • 1Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada.

Nature
|January 26, 2000
PubMed
概括

适应蛋白Cbl-b对于维持免疫耐受性至关重要. 在小鼠中缺少它会导致自身免疫,这是由于不受控制的淋巴细胞激活和自身抗体的产生.

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