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Murine Model of CD40-activation of B cells
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Cbl-b调节了T细胞激活的CD28依赖性

Y J Chiang1, H K Kole, K Brown

  • 1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.

Nature
|January 26, 2000
PubMed
概括

适应分子Cbl-b调节T细胞激活,因为缺乏Cbl-b的T细胞不需要CD28的共同刺激来产生互白素-2. 缺乏Cbl-b可恢复抗体反应并增强VaV激活,从而影响自身免疫性疾病的易感性.

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