麻疹病史和亚托皮性疾病:基于人口的横截面研究
M Paunio1, O P Heinonen, M Virtanen
1Department of Public Health, University of Helsinki, Finland. mikko.paunio@stm.vn.fi
JAMA
|January 27, 2000
概括
自然麻疹感染与疹,鼻炎和喘等亚托皮性疾病的风险更高有关. 这项研究没有发现任何证据表明麻疹可以预防这些疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 横截面研究表明,减少对传染病 (包括麻疹) 的暴露,与富裕国家形疾病发病率的增加有关.
- 卫生假设提出,早年接触病原体可能会防止过敏状况.
研究的目的:
- 调查天然麻疹感染与阿托皮性疾病的流行程度之间的联系.
- 为了确定自然麻疹感染是否能提供对亚托皮的保护.
主要方法:
- 在芬兰 (1982-1986) 进行了一项全国性的横截面研究,分析了547,910名14个月至19岁的个体的数据.
- 在接种麻疹-疹-红疹 (MMR) 疫苗时,收集了麻疹发生率和无形症状 (湿疹,鼻炎,喘) 的数据.
- 计算了患病率,以比较有或没有麻疹病史的个体的亚托皮率.
主要成果:
- 患有麻疹病史的个体显示,阿托皮性疾病的年龄调整后患病率显著更高.
- 湿疹的患病率为1.32,鼻炎为1.41和喘为1.67.
- 这种关联在所有年龄段,城市/农村环境以及不同程度的社会接触中都是一致的.
结论:
- 这些发现表明,麻疹感染和亚托皮之间存在积极的关联.
- 结果不支持假设自然麻疹感染提供防治亚托皮性疾病的保护.
- 麻疹和亚托皮似乎比预期的更频繁地同时发生.
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