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相关概念视频

Membrane Carbohydrates01:30

Membrane Carbohydrates

The plasma membrane is a dynamic barrier composed of lipids, proteins, and carbohydrates. It is the epicenter of many cellular processes required for cell growth and survival. Carbohydrates have unique structural and chemical properties that help the plasma membrane to carry out its functions effectively.
Membrane carbohydrates do not have any hydrophobic region and are exclusively located on the cell's outer surface. The addition of sugar molecules or glycosylation of proteins happens in...
Membrane Carbohydrates01:30

Membrane Carbohydrates

The plasma membrane is a dynamic barrier composed of lipids, proteins, and carbohydrates. It is the epicenter of many cellular processes required for cell growth and survival. Carbohydrates have unique structural and chemical properties that help the plasma membrane to carry out its functions effectively.
Membrane carbohydrates do not have any hydrophobic region and are exclusively located on the cell's outer surface. The addition of sugar molecules or glycosylation of proteins happens in...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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相关实验视频

Updated: Jul 10, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
11:01

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

通过核酸胺体的自适应性识别.

T Hermann1, D J Patel

  • 1Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. thermann@sbnmr1.ski.mskcc.org

Science (New York, N.Y.)
|February 5, 2000
PubMed
概括
此摘要是机器生成的。

核酸体被选择用于高亲和度与特定分子的结合. 结构研究揭示了关键相互作用,如堆叠,键和形状互补性,反映了细胞识别事件.

更多相关视频

Visual Detection of Multiple Nucleic Acids in a Capillary Array
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Visual Detection of Multiple Nucleic Acids in a Capillary Array

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A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate (NMDA) Receptor in Blood
07:20

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate (NMDA) Receptor in Blood

Published on: January 9, 2018

相关实验视频

Last Updated: Jul 10, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
11:01

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase

Published on: November 23, 2016

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate (NMDA) Receptor in Blood
07:20

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate (NMDA) Receptor in Blood

Published on: January 9, 2018

科学领域:

  • 分子生物学分子生物学
  • 生物化学 生物化学
  • 结构生物学 结构生物学

背景情况:

  • 核酸是基因信息处理的基础.
  • 亚体是为特定的连接物结合而选择的核酸序列.
  • 了解胺体-配体相互作用是生物识别的关键.

研究的目的:

  • 阐明阿普坦 - 连接体特异性的结构基础.
  • 为了确定驱动aptamer结合的关键分子相互作用.
  • 为了比较aptamer识别原理与细胞核酸相互作用.

主要方法:

  • 在实验室中从随机序列图书馆中选择体.
  • 高分辨率的三维结构测定阿普坦 - 连接体复合体.
  • 确定结构内的分子相互作用的分析.

主要成果:

  • 证实了高亲和度和特异性结合的aptamers到目标合体.
  • 详细的结构揭示了特定的分子相互作用:堆叠,键,形状互补性.
  • 这些相互作用对于胺体-联结体关联的特异性至关重要.

结论:

  • 结构性洞察力解释了胺体-连接体结合的高特异性.
  • 调节阿普坦体识别的原则与涉及核酸的基本细胞分子识别事件相似.