在成年脊髓中感觉轴突的功能再生
M S Ramer1, J V Priestley, S B McMahon
1Neuroscience Research Centre, Guy's, King's and St. Thomas' School of Biomedical Sciences, London, UK. matt.ramer@kcl.ac.uk
Nature
|February 5, 2000
概括
神经营养不良因素,如神经生长因子 (NGF) 和质衍生神经营养不良因子 (GDNF),在受伤后促进感觉轴突再生到脊髓中. 这种功能性重新连接有助于从背部根突破损伤中恢复.
科学领域:
- 神经科学是一个神经科学.
- 再生医学是一种再生医学.
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- 轴突再生在外周中枢神经系统过渡区受到阻碍.
- 这种再生障碍一直是神经科学中长期存在的挑战.
研究的目的:
- 为了研究是否可靠的支持可以克服轴突再生障碍.
- 评估特定神经变因子在促进背根轴突再生和功能恢复方面的有效性.
主要方法:
- 成年大鼠的背部根部受伤,用各种神经营养因子 (NGF,NT3,GDNF,BDNF) 进行治疗.
- 通过背部根进入脊髓的区域评估了轴突的再生.
- 通过观察背部角神经元中的功能反应,证实了突触重新连接.
- 行为测试评估了感官功能的恢复,如热量和压力敏感性.
主要成果:
- 神经生长因子 (NGF),神经营养素-3 (NT3) 和质细胞系衍生的神经营养因子 (GDNF) 促进了选择性的轴突再生.
- 脑衍生神经营养因子 (BDNF) 没有产生显著的再生效应.
- 在接受神经变因子治疗的老鼠中,实现了功能性突触重新连接.
- 用NGF和GDNF治疗的老鼠表现出对有害热量和压力的敏感性恢复.
结论:
- 营养支持,特别是NGF,NT3和GDNF,可以克服边缘-中枢神经系统接口的再生障碍.
- 神经缩因子治疗在背部根突破损伤后促进功能恢复和感官恢复.
- 这种方法有望成为脊髓损伤的可行的治疗策略,其中包括根部脱落.
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