人类对饮用水的压力反应:一个同情的反射?
J Jordan1, J R Shannon, B K Black
1Clinical Research Center, Franz Volhard Clinic, Berlin, Germany.
Circulation
|February 9, 2000
概括
饮用水通过增加同情活动,显著提高自主功能衰竭患者的血压. 这一发现为静止性低血压提供了潜在的治疗方法,并突出了水的作用.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统功能 自主神经系统功能
背景情况:
- 饮用水会在自主功能衰竭患者和老年人中急剧提高血压.
- 这种压力反应的潜在生理机制尚不清楚.
研究的目的:
- 研究自主功能衰竭患者和对照组的摄入水后血压反应.
- 阐明饮用水压力效应的机制.
主要方法:
- 在47名自主性衰竭患者 (多系统缩和纯自主性衰竭) 和对照组中,评估了饮水后坐着的血压变化.
- 测量了血中的诺阿皮内弗林,蛋白活性,血管压素和血液体积.
- 利用三甲输液来探索同情功能的作用.
主要成果:
- 在自主功能衰竭患者摄入水后观察到深度缩血压升高 (33-37 mm Hg).
- 在年龄较大的对照组中显著增加静脉压 (11 mm Hg),但在年轻的对照组中并非如此.
- 饮用水在患者和对照组中都提高了血中诺亚上腺素水平,这表明了同情激活.
结论:
- 口服饮用水快速显著增强了交感神经系统的活动.
- 水的这种压力效应在自主性衰竭中是显著的,可能有助于正静性低血压管理.
- 水的压力效应是临床试验中涉及心血管药物的关键,经常被忽视的因素.
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