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在Cx43缺乏的小鼠中,因缺血引起的腹腔失常的加速发病和增加发病率.

D L Lerner1, K A Yamada, R B Schuessler

  • 1Departments of Pediatrics, Medicine, Surgery, and Pathology, and The Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA.

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|February 9, 2000
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概括
此摘要是机器生成的。

在小鼠中,减少了连xin43 (Cx43) 表达,在急性缺血期间显著增加了腹腔动脉节律不良. 这突出了电气合在预防冠状动脉堵塞后心律失常的关键作用.

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科学领域:

  • 心血管生理学心血管生理学
  • 心脏电生理学 心脏电生理学
  • 节律失常的研究研究arrhythmogenesis.

背景情况:

  • 心肌缺血导致心脏电气性质的复杂变化.
  • 区分个人对缺血引起的心律失常的贡献是具有挑战性的.
  • 连接素43 (Cx43) 对于心室电气合至关重要.

研究的目的:

  • 调查减少电气合在急性缺血引起的腹腔动脉节律失常症中的作用.
  • 为了比较野生型和Cx43+/-小鼠中的心律失常.

主要方法:

  • 急性心肌缺血被诱导在隔离的 perfused 小鼠心脏.
  • 左前下垂冠状动脉封闭被用来建模缺血.
  • 监测和比较Cx43+/-和野生型 (Cx43+/+) 小鼠之间的心律失常.

主要成果:

  • Cx43+/-的心脏表现出自发和诱导的腹腔动脉节律失常 (VT) 的发生率和频率显著更高.
  • 在Cx43+/-心中,VT的发病时间较早,而在Cx43+/-心中,跑步更频繁,更长时间.
  • 在Cx43+/-心脏中,早发性心室跳动更为常见,而低流区域大小没有差异.

结论:

  • 减少Cx43表达在急性缺血期间加速和加剧心室节律失常.
  • 减少电气合是缺血引起的心律失常的一个关键因素.
  • 在缺血事件期间,Cx43在维持心脏电稳定性方面发挥着至关重要的作用.