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相关概念视频

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...

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相关实验视频

Updated: May 7, 2026

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
12:17

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay

Published on: January 19, 2012

脊椎动物发育中的节点信号.

A F Schier1, M M Shen

  • 1Department of Cell Biology, New York University School of Medicine, New York 10016, USA. schier@saturn.med.nyu.edu

Nature
|February 10, 2000
PubMed
概括
此摘要是机器生成的。

通过节点信号通路进行细胞通信对于在早期胚胎发生过程中建立脊椎动物身体计划至关重要. 该途径调节关键的发育事件,包括轴形成和组织模式.

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The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

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相关实验视频

Last Updated: May 7, 2026

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
12:17

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay

Published on: January 19, 2012

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
05:36

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

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科学领域:

  • 发育生物学是发展生物学.
  • 细胞信号传递 细胞信号传递
  • 分子生物学分子生物学

背景情况:

  • 细胞通信对于脊椎动物的胚胎发生和身体计划组织至关重要.
  • 节点信号通路是转变生长因子β超级家族的一员,在胚胎发育中起着核心作用.

研究的目的:

  • 阐明节点信号通路在脊椎动物胚胎发生中的作用.
  • 了解节点信号如何调节中皮层和内皮层的形成,轴的规范和神经模式.

主要方法:

  • 研究了节点信号通路及其调节器.
  • 专注于EGF-CFC辅因子和Lefty/Cerberus对手的细胞外调节.

主要成果:

  • 节点信号对于构建脊椎动物胚胎至关重要.
  • 细胞外调节器精确控制节点活动.
  • 节点通路活动影响中皮层/内皮层的形成,前后轴,神经模式和左右轴的规格.

结论:

  • 节点信号通路是脊椎动物早期发育的关键调节器.
  • 通过特定的蛋白家族对节点活动的细胞外调制确保了精确的胚胎模式.