运动期间的舒张血压变化与血清胆固醇和胰岛素耐药性正相关
S E Brett1, J M Ritter, P J Chowienczyk
1Department of Clinical Pharmacology, Centre for Cardiovascular Biology and Medicine, King's College, St Thomas' Hospital, London SE1 7EH, UK. s.brett@umds.ac.uk
Circulation
|February 15, 2000
概括
轻度炼期间的舒张血压变化与胆固醇和胰岛素抵抗水平有关. 这些代谢因素可能会导致高血压的风险人群.
科学领域:
- 心血管生理学心血管生理学
- 代谢健康 代谢健康
- 运动科学 运动科学
背景情况:
- 诸如胆固醇和胰岛素抵抗等代谢因素可能通过血管反应性影响血压.
- 这些影响可能在运动时比在休息时更明显.
研究的目的:
- 为了研究血清胆固醇,胰岛素抵抗和轻度运动期间血压变化之间的联系.
- 确定健康男性运动期间血压反应的预测因子.
主要方法:
- 在75名健康男性中测量了静止状态和低工作负载自行车人体能测 (50-100W) 的血压.
- 评估血清胆固醇和胰岛素抵抗 (禁食葡萄糖-胰岛素产品).
- 利用逐步回归来识别血压变化的独立预测因素.
主要成果:
- 休息时血压与胆固醇或胰岛素抵抗没有显著的相关性.
- 运动期间的透气血压变化与血清胆固醇 (R>0.47) 和胰岛素抵抗 (R>0.38) 有显著的相关性.
- 血清胆固醇和胰岛素耐药性是运动期间透静血压变化的独立预测因素.
结论:
- 在温和运动期间的透气血压变化与总胆固醇和胰岛素抵抗强烈相关.
- 这些发现表明,在失脂症和胰岛素耐药患者中,高血压并发症的潜在机制.
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