激素替代疗法和乳房扫描查的准确性
A M Kavanagh1, H Mitchell, G G Giles
1Cancer Epidemiology Centre, Anti-Cancer Council of Victoria, Australia. A.Kavanagh@latrobe.edu.au
Lancet (London, England)
|February 16, 2000
概括
激素替代疗法 (HRT) 的使用显著降低了乳房扫描查的准确性,导致更多的假负和假阳性. 这种降低灵敏度可能会影响乳腺癌查计划的有效性.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 激素替代疗法 (HRT) 是女性广泛使用的.
- 对于公共卫生倡议来说,HRT对乳房扫描检查准确性的影响是一个重大问题.
- 准确的乳房造影对于早期发现乳腺癌至关重要.
研究的目的:
- 评价HRT对乳腺查敏感性和特异性的影响.
- 确定HRT使用是否影响小乳腺癌的检测率.
- 评估HRT使用对乳房影像假阴性和假阳性结果的影响.
主要方法:
- 这是一项大规模的研究,对澳大利亚的103770名女性进行了第一轮乳房扫描查.
- 查数据的分析,以比较HRT使用者和非使用者之间的敏感性,特异性和小癌症检测率.
- 使用后勤回归建模来调整诸如年龄,家族病史和症状状况等混因素.
主要成果:
- 与非使用者 (77.3%) 相比,HRT使用者 (64.8%) 的乳房扫描灵敏度较低.
- HRT使用者更有可能获得错误的负结果 (OR 1.60) 和错误的正结果 (aOR 1.12).
- 在HRT使用者中,特异性略有降低.
结论:
- 激素替代疗法使用明显降低了乳房扫描查的敏感性.
- 与HRT相关的精度降低可能会损害基于人口的查计划的死亡率益处.
- 医疗保健提供者应考虑HRT状态在解释乳房影像时,以优化乳腺癌检测.
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