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Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry
Published on: May 17, 2016
系统性血压和死亡率
1Department of Mathematics, University of California, Los Angeles 90025, USA. sport@ucla.edu
Lancet (London, England)
|February 16, 2000
概括
系统性血压风险并没有严格增加;存在一个值. 目前的高血压指南可能会根据年龄和性别对许多成年人错误分类风险.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 目前的高血压指南使用了所有成年人140毫米的缩血压值.
- 世界卫生组织和国际高血压学会的建议建议较低的正常 (130毫米升) 和最佳 (120毫米升) 压力.
- 这些指导方针假定系统血压和死亡率之间严格增加的关系,这在很大程度上是基于弗雷明汉研究.
研究的目的:
- 重新评估弗雷明汉研究数据,以确定心血管和整体死亡风险是否严格依赖于静脉压,或者是否存在值.
- 挑战线性假设,对缩血压和死亡率增加风险模型的假设.
主要方法:
- 利用后勤线条来建模缩血压和死亡风险 (心血管和全因) 之间的关系.
- 按年龄和性别的就业率.
- 对斜率参数与年龄和性别的独立性进行了测试,采用了非传统物流模型的常见斜率的减少模型.
主要成果:
- 弗雷明汉数据拒绝了传统的线性物流模型.
- 无论是全因还是心血管死亡率都没有显示出严格地增加对缩血压的依赖.
- 风险独立于静脉压低于特定的年龄和性别依赖的值 (大约在第70个百分位),而在第80个百分位以上急剧增加.
结论:
- 弗雷明汉数据与这样一种观点相矛盾,即较低的缩血压普遍意味着较低的风险.
- 由于年龄和性别的风险值,140 mm Hg的高血压切断值并不普遍适用.
- 根据这些发现,目前被认为有增加风险的人口中很大一部分可能没有.
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