在艾滋病毒感染的男性中,丸激素替代和抵抗运动导致体重减轻和低丸激素水平
S Bhasin1, T W Storer, M Javanbakht
1Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA. sbhasin@ucla.edu
JAMA
|February 22, 2000
概括
替代和抵抗运动可以改善低的HIV感染男性的肌肉力量和身体组成. 这两种干预措施都有效地增加了瘦身质量和力量,但将它们结合起来没有额外的好处.
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 传染性疾病 传染性疾病
背景情况:
- 以前对艾滋病毒感染男性丸激素补充剂的研究没有显示肌肉强度有所改善.
- 在这个人群中,抵抗运动和丸激素补充剂的联合效果仍然是未知的.
研究的目的:
- 评估替代疗法 (TRT) 带有和没有抵抗运动对肌肉力量和身体组成的影响.
- 为了评估感染艾滋病毒的男性体验低丸激素水平和减肥的结果.
主要方法:
- 一个16周的,安慰剂控制的,双盲的,随机的临床试验.
- 招募了61名感染艾滋病毒的男性 (年龄在18-50岁),他们的丸激素水平较低,体重显著下降.
- 将参与者分配到四组:安慰剂,单独使用丸激素,安慰剂与运动,或丸激素与运动.
主要成果:
- 在接受丸激素或运动的组中,观察到体重,肌肉强度 (腿压,腿卷曲,长椅压,拉拉拉),大腿肌肉体积和瘦身量显著增加.
- 与单独安慰剂相比,丸激素运动和单独运动组的力量增加更大.
- 丸激素补充导致血红蛋白水平增加.
结论:
- 和阻力运动独立地促进了艾滋病毒感染的男性的体重,肌肉质量和力量的显著增加,这些男性患有阴道腺症和体重减轻.
- 与单独干预相比,丸激素和运动的联合治疗没有产生更好的结果.
相关概念视频
Retrovirus Life Cycles
43.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
43.0K
Testosterone: Functions and Regulation
3.4K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
3.4K
Sexually Transmitted Infections
2.0K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
2.0K
Pulmonary Tuberculosis I
1.7K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K


