在年轻男性中,口服androstenedione的使用和血清丸激素度
B Z Leder1, C Longcope, D H Catlin
1Department of Medicine, Massachusetts General Hospital, Boston 02114, USA.
JAMA
|February 22, 2000
概括
在健康男性中,口服安德罗二补充剂每天300毫克显著增加了和雌激素水平. 较低剂量对没有显著影响,突出显示了剂量依赖的荷尔蒙反应.
科学领域:
- 内分泌学 在内分泌学.
- 运动医学 运动医学
- 营养科学 营养科学
背景情况:
- 安德罗斯二是丸激素的前体,可以在没有处方的情况下使用.
- 它对运动表现的所谓好处缺乏确立的荷尔蒙证据.
研究的目的:
- 为了研究口服安德罗二对健康男性血清丸激素水平的影响.
- 为了确定剂量依赖的荷尔蒙变化.
主要方法:
- 开放式随机对照试验,对42名健康男性 (20-40岁) 进行随机对照试验.
- 参与者每天服用0,100毫克或每天服用300毫克的口服androstenedione,持续7天.
- 血清丸激素,androstenedione,雌激素和雌激素水平通过频繁的血液采样进行测量.
主要成果:
- 300毫克/天安德罗斯二醇组显示丸激素显著增加 (34%的AUC,P<.001).
- 100毫克/天组没有显著改变丸激素水平 (-4%的AUC,P=.48).
- 在100 mg/d (42% AUC,P=.002) 和300 mg/d (128% AUC,P<.001) 组中,雌激素水平显著增加,个体差异很大.
结论:
- 在一些健康的男性中,口服androstenedione每天300毫克可以增加血清丸激素和雌激素度.
- 荷尔蒙效应依赖于剂量,并表现出显著的个体间变化.
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