在静止性刺激期间,交感神经放电和心血管变量中的振荡模式
1Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale L. Sacco, and Centro LITA di Vialba, Università degli Studi di Milano, Milan, Italy. raffaellof@fisiopat.sacco.unimi.it
Circulation
|March 1, 2000
概括
在抬头倾斜时,肌肉交感神经活动 (MSNA) 和心率变化具有共同的低频 (LF) 振荡模式. 这表明在交感激活过程中同步的神经交感放电和心血管调节.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的调节规则
- 神经科学是一个神经科学.
背景情况:
- 交感神经系统的活动会影响心率和血压.
- 抬头倾斜是评估自主反应的常见动作.
- 了解同情活动中的振荡模式对于心血管健康至关重要.
研究的目的:
- 为了调查肌肉交感神经活动 (MSNA) 和心血管变异性是否在交感激活期间具有共同的振荡模式.
- 为了确定MSNA变化的低频 (LF) 组成部分是否与头向上倾斜期间的心血管节奏有关.
主要方法:
- 10名健康人接受了脑电图,动脉压和MSNA记录,这些记录是在卧卧的休息和75度的抬头倾斜时进行的.
- 用光谱和跨光谱分析来评估R-R间隔的LF (0.1Hz) 和HF (0.27Hz) 组件,静脉压 (SAP) 和MSNA.
- 在休息和倾斜时测量了catecholamine水平.
主要成果:
- 抬头倾斜会增加心率,MSNA和血类甲基醇胺,表明交感活性增强.
- 在倾斜时,MSNA变化的LF组件 (LF(MSNA)) 增加,反映了R-R间隔和SAP变化的LF组件的增加.
- 在倾斜过程中,MSNA,R-R间隔和SAP的LF组件之间的合得到了增强.
结论:
- 一种常见的振荡模式,以增加LF节奏为特征,在头向上倾斜诱导的交感激活期间,在神经交感放电,心率变化和动脉压变化中出现.
- 这表明在生理性压力期间心血管功能的同步自主调节.
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