最近的胸膜移民对HIV-1疾病进展的影响
A Hatzakis1, G Touloumi, R Karanicolas
1Department of Hygiene and Epidemiology, Athens University Medical School, Greece.
Lancet (London, England)
|March 4, 2000
概括
较低的T细胞受体重组切除DNA循环 (TREC) 水平预测更快的HIV-1疾病进展. 测量TREC,以及病毒载量和CD4计数,有助于预测HIV-1患者的临床结果.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 在外围T细胞中的T细胞受体重新排列切除DNA圆 (TREC) 表明最近的胸膜移民.
- TREC水平是免疫复原和疾病进展的潜在生物标志物.
研究的目的:
- 评估TREC度对HIV-1感染个体临床结果的预测值.
- 评估TREC与已确定的生物标志物 (如CD4 T细胞计数和HIV-1 RNA负载) 结合的预后意义.
主要方法:
- 在外围血液单核细胞中使用实时PCR测定量化TREC度.
- 来自已知HIV-1血清转换日期的多中心血友病队列研究的131名希腊参与者的队列被分析.
- 使用Kaplan-Meier和Cox的回归分析来评估预后值.
主要成果:
- 较低的基线TREC值在与没有进展到艾滋病的人相比,在进展到艾滋病的个体中观察到 (p=0.017).
- 增加的TREC水平与更高的艾滋病进展 (aHR=1.44) 和死亡 (aHR=1.52) 的相对风险相关,独立于病毒载量和CD4计数.
- 艾滋病毒-1RNA负载和CD4T细胞计数也独立预测疾病进展和死亡.
结论:
- 周围T细胞池中的TREC度是对HIV-1RNA负载和CD4T细胞计数的有价值补充,用于预测HIV-1疾病进展率.
- 根据TREC水平,最近的胸膜移民在HIV-1疾病的发病过程中发挥了作用.
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