在结直肠瘤中表达了垂体瘤转化基因
A P Heaney1, R Singson, C J McCabe
1Department of Medicine, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, USA.
Lancet (London, England)
|March 7, 2000
概括
下垂体瘤转化基因 (PTTG1) 在结直肠瘤中表达高,与侵袭性有关. 增加的PTTG1可能表明侵袭性结直肠癌,并作为治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 基本纤维细胞生长因子 (FGF2) 在结肠癌中促进血管新生和髓新生.
- 下垂体瘤转化基因 (PTTG1) 驱动细胞转化并调节FGF2分泌.
- 在正常组织中,PTTG1通常表达不充分,但在癌细胞中却很丰富.
研究的目的:
- 为了研究PTTG1表达和结直肠瘤的侵入性之间的关系.
- 评估PTTG1作为入侵性结直肠癌的潜在生物标志物.
主要方法:
- 在68个结直肠瘤中量化了PTTG1基因和蛋白质表达.
- 表达水平与侵入性特征进行了比较:淋巴结转移,瘤血管性和FGF2表达.
- PTTG1表达正常化到相邻的正常结直肠组织.
主要成果:
- 与正常组织相比,PTTG1在所有分析的结肠癌和息肉中都过度表达.
- 较高的PTTG1表达与淋巴结入侵有显著的相关性 (p=0.007).
- 在更多的血管瘤中观察到增加的PTTG1水平 (p=0.04).
结论:
- 结直肠瘤中PTTG1表达升高与侵入性增加有关.
- PTTG1可以作为一种有价值的生物标志物,用于识别侵袭性结直肠癌.
- PTTG1代表了结直肠癌治疗的潜在新型治疗标.
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