轻度冠状动脉疾病和内皮功能障碍患者的长期随访
J A Suwaidi1, S Hamasaki, S T Higano
1Center for Coronary Physiology and Imaging, Division of Cardiovascular Diseases, and Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Circulation
|March 7, 2000
概括
患有严重冠状动脉内皮功能障碍的患者,即使没有明显的阻塞,也面临心脏病发作和死亡等心脏事件的更高风险. 这突出了内皮功能.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 冠状动脉内皮功能障碍包括对乙胆的异常血管收缩.
- 它被认为是冠状动脉样硬化的早期迹象.
- 基于内皮功能水平的患者结局存在有限的数据.
研究的目的:
- 为了评估轻度冠状动脉疾病患者的临床结果,根据其内皮功能分层分层.
- 为了研究冠状动脉内皮功能障碍的预后价值.
主要方法:
- 157名患有轻度冠状动脉疾病的患者接受了冠状动脉血管反应性测试,使用乙胆,腺和酸甘油,以及冠状动脉内超声波.
- 根据乙胆反应,患者被分为正常 (n=83),轻度 (n=32) 和严重 (n=42) 的内皮功能障碍组.
- 结果在平均28个月的随访期内被跟踪.
主要成果:
- 在正常或轻度内皮功能障碍的患者中,没有发生心脏事件.
- 14%的患有严重内皮功能障碍的患者经历了心脏事件,包括心肌梗塞,再血管或心脏死亡 (P<0.05).
- 在严重功能障碍组中,共记录了10次心脏事件.
结论:
- 严重的内皮功能障碍,独立于阻塞性冠状动脉疾病,与显著更高的心脏不良事件风险有关.
- 这些发现表明,冠状动脉内皮功能障碍在冠状动脉样硬化的进展中起着至关重要的作用.
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