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血液透析通过氧化应激损害内皮功能:维生素E涂层透析器的影响
H Miyazaki1, H Matsuoka, H Itabe
1Department of Internal Medicine III and the Cardiovascular Research Institute, Kurume University School of Medicine, Kurume, Japan.
Circulation
|March 7, 2000
概括
血液透析通过增加氧化应激来损害内皮功能. 使用维生素E涂层透析器可以防止这种功能障碍,这突出了血液透析患者潜在的治疗策略.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物医学工程 生物医学工程
背景情况:
- 接受血液透析的患者表现出加速动脉样硬化和增加的死亡率.
- 内皮功能障碍是动脉样硬化的前体和加重因素.
- 血液透析对内皮功能的直接影响尚不清楚.
研究的目的:
- 为了调查血液透析本身是否会诱导内皮功能障碍.
- 评估氧化应激在血液透析诱导的内皮功能障碍中的作用.
- 评估抗氧化血液透析膜在保护内皮功能方面的有效性.
主要方法:
- 通过高分辨率超声波多普勒心声学 (Doppler echocardiography) 使用流介导血管扩张 (FMD) 评估内皮功能.
- 氧化应激通过氧化低密度脂蛋白 (LDL) 的血水平来测量.
- 用维生素E涂层的透析剂来研究血液透析期间的抗氧化修饰.
主要成果:
- 一次使用非涂层透析剂的单次血液透析会削弱口病和增加氧化LDL水平.
- 用维生素E涂层膜进行血液透析,防止了口炎的恶化和氧化LDL的增加.
- 血氧化LDL水平与口病有显著的反相关性 (r=-0.53,P<0.001).
结论:
- 血液透析本身似乎会损害内皮功能.
- 增加的氧化应激是可能导致血液透析诱导的内皮功能障碍的机制.
- 抗氧化血液透析膜可以防止与透析相关的内皮损伤.
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