相关实验视频
Updated: May 13, 2026

10:59
New Methods to Study Gustatory Coding
Published on: June 29, 2017
热刺激味觉的热刺激
1The John B. Pierce Laboratory, Yale School of Medicine, New Haven, Connecticut 06519, USA.
Nature
|March 8, 2000
概括
舌头上的温度变化可以令人惊地唤起甜味,酸味和味等味觉. 这项研究揭示了味觉神经的热敏度,挑战了以前关于味觉系统的假设.
科学领域:
- 神经科学是一个神经科学.
- 感官科学 感官科学
- 味觉系统研究 味觉系统研究
背景情况:
- 电生理学记录显示,哺乳动物的味觉神经具有显著的热敏感性.
- 以前人们认为,味觉系统内的温度刺激不会引起味觉.
研究的目的:
- 调查舌头的热刺激是否可以诱导味觉.
- 探索温度在人类味觉系统神经编码中的作用.
主要方法:
- 应用局部加热和冷却到前后舌头的特定区域.
- 记录了相关味觉神经的电生理学反应 (带和耳鼻).
主要成果:
- 从寒冷状态温暖舌头的前部唤起了甜味.
- 冷却前面的舌头引起了酸味和/或味.
- 在舌头后部观察到明显的热味关系.
结论:
- 舌头的热刺激可以直接引起味觉.
- 人类的味觉系统拥有多样化的热敏神经元,有助于味觉感知.
- 这些发现挑战了先前的假设,并突出了温度在味道编码中的作用.
相关概念视频
The Tongue and Taste Buds
The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.
Gustation
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
Thermosensation
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Taste Buds and Receptors
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
The Physiology of Taste
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the diffusion of...
Salivary Glands and Saliva
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...

