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由p21cip1/waf1维持的造血干细胞静止状态

T Cheng1, N Rodrigues, H Shen

  • 1Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Science (New York, N.Y.)
|March 10, 2000
PubMed
概括

G1检查点调节器,p21,对于造血干细胞 (HSC) 静止至关重要. 没有p21,HSC会过度繁殖,导致疲劳和失败,特别是在压力下.

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