ангиотензин II 在人类心脏纤维细胞中具有多种益菌性作用
1Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, University of California at Los Angeles School of Medicine, CA 90024, USA.
Circulation
|March 15, 2000
概括
ангиотензин II (Ang II) 激活人类心脏细胞中的AT1受体,促进心脏纤维化. 这项研究揭示了Ang II在增加纤维细胞粘附和通过AT(1) 受体信号传递来增加细胞外矩阵积累中的作用.
科学领域:
- 心血管生物学 心血管生物学
- 细胞和分子医学是细胞和分子医学.
- 纤维化研究 纤维化研究
背景情况:
- ангиотензин II (Ang II) 与心脏重塑有关,并具有益菌作用.
- 了解Ang II对人类心脏纤维细胞的直接影响对于心脏纤维化研究至关重要.
研究的目的:
- 研究Ang II对人类心脏纤维细胞的直接细胞效应.
- 确定Ang II在纤维细胞生长,细胞外基质积累和粘附中的作用.
- 确定介导这些效应的特定Ang II受体.
主要方法:
- 人类心脏纤维细胞被从心脏中分离出来.
- 细胞用Ang II和特定受体对抗剂 (伊布沙坦,PD 123319,迪瓦利尼尔) 进行治疗.
- 试验包括测量基因激活蛋白激酶活性,DNA合成,mRNA水平 (TGF-β1,拉米林,纤维素,PAI-1),以及纤维细胞对原的附着.
主要成果:
- 格II显著增加了纤维细胞DNA合成,TGF-β1,拉米宁和纤维菌素mRNA水平.
- Ang II增强了等离子素激活剂抑制剂-1表达和心脏纤维细胞对原的附着.
- 这些效应仅通过AT(1) 受体进行介导,因为它们被irbesartan阻断.
结论:
- 在人类心脏细胞中通过Ang II激活AT(1) 受体促进心脏纤维化.
- 安格II在刺激等离子体激活剂抑制剂-1表达方面发挥着新的作用.
- 格II增强心脏纤维细胞对原的粘附,有助于纤维化过程.
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