由长时间的快速心房节奏引起的心房动与心房交感内置的异质变化有关
J V Jayachandran1, H J Sih, W Winkle
1Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Circulation
|March 15, 2000
概括
在心房动 (AF) 期间持续的快速心率会增加心房中的交感神经活动. 这种改变的自主内与心房电活动的变化相关.
科学领域:
- 心脏病学 心脏病学
- 自主神经科学 自主神经科学
- 电力生理学 电力生理学
背景情况:
- 心房动 (AF) 涉及结构和电生理学变化,由于快速的速度.
- 持续性AF对心房自主内置的影响尚不清楚.
- 这项研究研究了快速心房率与心房自主内置之间的关系.
研究的目的:
- 为了确定持续的快速心房率是否会改变心房的自主内尔化.
- 探索AF期间电生理学改造和自主变化之间的相关性.
主要方法:
- 六只狗接受了每分钟600次的心房节拍,以诱导持续的AF.
- 使用[C-11]基 (HED) 的正子发射断层扫描用于评估交感神经末端密度.
- 分析了上腺素度和心房电生理学.
主要成果:
- 与对照犬相比,节奏狗在心房组织中显示出明显更高的HED保留和北上腺素度.
- 前庭交感内置是异质的,右前庭的HED保留更大.
- 在右心房,心房动周期的长度较长,并且随着兰醇治疗而增加.
结论:
- 在AF的快速率导致心房交感内置异质增加.
- 这些自主变化与AF的明显的电生理效应有关.
相关概念视频
Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Disturbances in Heart Rhythm
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias II: Classification of Tachyarrhythmias
Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
Dysrhythmias III: Characteristics of Dysrhythmias
Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per minute.
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...


