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成年哺乳动物眼中的视网膜干细胞
V Tropepe1, B L Coles, B J Chiasson
1Department of Anatomy and Cell Biology, University of Toronto, Medical Sciences Building 1105, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Science (New York, N.Y.)
|March 17, 2000
概括
科学家们在小鼠眼睛中发现了成年视网膜干细胞,为视网膜再生提供了潜力. 这些细胞位于纤毛边缘,可以发展成各种视网膜细胞类型.
科学领域:
- 眼科医生 眼科 眼科
- 发展生物学 发展生物学
- 干细胞研究 干细胞研究
背景情况:
- 成熟的哺乳动物视网膜传统上缺乏再生能力.
- 了解视网膜再生对于治疗视力丧失至关重要.
研究的目的:
- 在成年哺乳动物视网膜内识别干细胞.
- 为了研究这些已识别的细胞的再生潜力.
主要方法:
- 单色素的纤毛边缘细胞的分离和克隆增殖 in vitro.
- 对细胞分化成视网膜特异性细胞类型的评估.
主要成果:
- 在成年小鼠的纤毛边缘中识别干细胞群.
- 克隆增殖和分化成杆光受体,双极神经元和穆勒细胞的演示.
- 这些干细胞的定位在纤毛边缘,与视网膜色素表皮不同.
结论:
- 成年老鼠的眼睛在纤毛边缘内含有具有再生潜力的干细胞.
- 这些视网膜干细胞可能与非哺乳动物脊椎动物的干细胞相同.
- 这一发现为未来的视网膜再生策略提供了基质.
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