良性卵巢囊和卵巢癌:一个队列研究,对查有影响
T J Crayford1, S Campbell, T H Bourne
1Department of Epidemiology and Public Health, Guy's, King's, and St Thomas' School of Medicine, King's College Hospital, London, UK. tim@crayford.net
Lancet (London, England)
|April 1, 2000
概括
在一次查试验中,切除良性卵巢囊并没有减少卵巢癌死亡. 有效的查需要敏感,具体和廉价的测试,以在健康的妇女中进行早期检测.
科学领域:
- 妇科瘤学 妇科瘤学
- 预防医学 预防医学
- 流行病学 流行病学
背景情况:
- 良性卵巢囊成为癌症的可能性是未知的.
- 研究这种联系可以为卵巢癌查策略提供信息.
- 一项研究评估了切除持久性囊是否会影响卵巢癌死亡率.
研究的目的:
- 为了确定持续性卵巢囊的外科切除是否与卵巢癌死亡率的减少有关.
- 评估囊切除作为卵巢癌查策略的有效性.
- 确定对未来卵巢癌查技术的需求.
主要方法:
- 分析了来自早期卵巢癌超声波查试验 (1981-1987) 的5479名女性的随访数据.
- 生命表方法计算了所有原因和特定癌症的预期死亡.
- 比例死亡率被计算出来,以比较实际和预期的死亡.
主要成果:
- 卵巢癌死亡人数 (22) 是预期的90%,卵巢癌的比例死亡率为128%.
- "健康志愿者效应"导致所有原因,所有癌症和卵巢癌的死亡人数低于预期.
- 在持续的卵巢囊去除和卵巢癌死亡率降低之间没有发现显著的关联.
结论:
- 手术切除持久性卵巢囊并没有降低预期卵巢癌死亡人数的比例.
- 针对健康妇女的基于人口的查需要针对早期恶性疾病进行特定,敏感和廉价的测试.
- 需要进一步的研究来开发有效的查工具,以早期检测卵巢癌.
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