与胃癌风险增加相关的互乐金-1多态
E M El-Omar1, M Carrington, W H Chow
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. elomare@mail.nih.gov
Nature
|April 4, 2000
概括
介素-1基因变异增加了Helicobacter pylori感染中低水和胃癌的风险. 这些遗传因素影响了互白素-1-β的产生,影响了胃酸分泌和疾病的结果.
科学领域:
- 胃肠病学 胃肠病学
- 免疫遗传学 免疫遗传学
- 在瘤学瘤学.
背景情况:
- 杆菌感染导致不同的临床结果,包括胃癌和十二指肠.
- 胃生理反应,如酸分泌和胃炎的严重程度,在感染者之间有很大的差异.
- 胃炎的分布 (腹腔与体) 影响酸分泌,体胃炎与低水和胃缩有关,这是癌症的前体.
研究的目的:
- 调查介质素-1基因群多态性与H. pylori感染个体中低水和胃癌的风险之间的关联.
- 探索互白素-1-β在调解宿主遗传与H. pylori相关疾病之间的联系中的作用.
主要方法:
- 分析介素-1基因群聚多态性,特别是那些疑似增强介素-1-β生产的基因群多态性.
- 评估特定多态体之间的链接不平衡,包括影响DNA-蛋白相互作用的TATA盒多态体.
- 识别的多形态与临床结果的相关性,如H. pylori感染人群中的低水和胃癌.
主要成果:
- 干白素-1基因群中的特定多态性与H. pylori诱导的低水症的风险增加有关.
- 这些多态性也与患胃癌的风险更高有关.
- 一个TATA-box多态体在体外对DNA-蛋白相互作用产生了显著影响,这表明了功能机制.
结论:
- 宿主遗传因素,特别是影响互白素-1-β的互白素-1基因集群的变异,在确定H. pylori感染的临床结果方面发挥着至关重要的作用.
- 介素-1-β,一种促炎性细胞因子和胃酸分泌的抑制剂,可能会调解观察到的关联.
- 了解这些遗传倾向可以帮助解释为什么只有一些H. pylori感染的个体会患上胃癌等严重疾病.
相关概念视频
03:18Non-LTR Retrotransposons
12.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.4K
01:12Loss of Tumor Suppressor Gene Functions
4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K
01:06Induced Pluripotent Stem Cells
4.8K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.8K
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
81
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
81
01:26Gastritis II: Pathophysiology
52
The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
52
01:25Inflammatory Bowel Disease III: Crohn's Disease
35
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
35