在急性心肌梗塞后,血清氨基终端甲基III型公与左心室功能的变化之间的关系
S H Poulsen1, N B Høst, S E Jensen
1Department of Internal Medicine, Division of Cardiology, Haderslev Hospital, Haderslev, Denmark.
Circulation
|April 4, 2000
概括
心肌梗塞 (MI) 后的III型公原氨基终端 (PIIINP) 水平预测了长期的左心室 (LV) 功能. 升高的PIIINP表明LV重塑较差,以及心脏病发作患者的预后更差.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 原蛋白的新陈代谢
背景情况:
- 第三种类型的氨基终端蛋白 (PIIINP) 反映了第三种类型的蛋白合成.
- PIIINP与心脏病发作 (MI) 的心肌梗塞大小和预后相关.
研究的目的:
- 调查PIIINP水平与急性心脏病发作后的长期左心室 (LV) 功能变化之间的关系.
- 评估PIIINP在预测MI后心脏不良事件中的预后价值.
主要方法:
- 血清PIIINP水平测定在47名第一次急性心脏病发作患者和16名对照组中.
- 在360天内,通过心声回声学来评估LV功能.
- 根据第4天的PIIINP水平 (5.0微克/L与>5.0微克/L),患者被分为两组.
主要成果:
- 患有较高PIIINP (>5.0微克/L) 的患者在LV喷射分数和LV体积增加方面没有显著改善.
- 较高的PIIINP水平与限制性LV透静填充有关.
- 升高的PIIINP和特定减速时间独立预测心脏死亡或心力衰竭.
结论:
- 在MI的亚急性阶段测量的PIIINP与长期的LV功能有关.
- PIIINP作为一个有价值的临床预后标志物,用于患者的MI.
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