长期的右心室体积过载会增加心肌中氧糖在心室间隔膜的吸收在患有心房隔膜缺陷的患者
1First Department of Internal Medicine, Tohoku University, Sendai, Japan.
Circulation
|April 12, 2000
概括
在心房隔膜缺陷患者中,长期的右心室体积过载会增加心肌中葡萄糖利用率,与左心室相比,心脏间隔膜的使用率会增加. 这项研究澄清了慢性RV过载下人类心脏的代谢变化.
科学领域:
- 心脏病学 心脏病学
- 核医学是一种核医学.
- 代谢研究研究 代谢研究
背景情况:
- 动物模型表明,长期的右心室 (RV) 过载会改变心肌能基质的新陈代谢.
- 由于慢性RV体积过载而导致的代谢变化的人类数据仍然有限.
研究的目的:
- 为了研究长期的RV体积过载是否会影响人类心肌能基质代谢.
- 为了比较心肌糖利用率,输液和心房隔膜缺陷 (ASD) 和健康对照患者之间的脂肪酸吸收.
主要方法:
- 使用[(18) F]氧糖 (FDG) 的正子发射断层扫描 (PET) 用于评估心肌中葡萄糖代谢率 (MMR).
- 单光子发射断层扫描 (SPECT) 使用[201]Tl]TlCl (Tl) 和[123) I]15-(p-二) -3-R,S-甲基五甲酸 (BMIPP) 评估了心肌输液和脂肪酸模拟物的吸收.
- 该研究包括11名ASD患者和11名对照患者.
主要成果:
- 在ASD患者中,MMR在心室间隔膜 (IVS) 与左心室 (LV) 自由壁相比显著增加 (420+/-35与333+/-32).
- 在对照组中,IVS和LV自由壁之间没有观察到MMR的显著差异 (347+/-27与357+/-25).
- 在两组中,SPECT成像显示IVS和LV自由壁之间的Tl或BMIPP吸收没有显著差异. 在IVS/LV自由壁比率中的MMR与ASD患者的VR体积过载指数相关.
结论:
- 在ASD患者中,长期的RV体积过载导致IVS中心肌葡萄糖利用率增加,相对于LV自由壁.
- 心肌输液和脂肪酸模拟剂的摄入量没有显著改变.
- 这表明在人类的慢性RV体积过载下,葡萄糖利用中的特定代谢适应.
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