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在缺乏素受体的小鼠中,损害了 nociception 和疼痛感觉

M J Caterina1, A Leffler, A B Malmberg

  • 1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143-0450, USA.

Science (New York, N.Y.)
|April 15, 2000
PubMed
概括

素 (素) 受体VR1对于感知热量和化学疼痛至关重要. 缺乏VR1的小鼠对痛苦的热量和化学物质的反应减少,突出显示了它在疼痛途径中的作用.

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Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...