矩阵金属蛋白酶-2有助于心脏中的缺血-再输液损伤
P Y Cheung1, G Sawicki, M Wozniak
1Departments of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Circulation
|April 19, 2000
概括
在再输液期间急性释放的矩阵金属蛋白酶 (MMP) 在缺血后恶化心脏功能. 抑制MMP可以治疗缺血-再输血损伤.
科学领域:
- 心血管研究研究心血管研究
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 矩阵金属蛋白酶 (MMPs) 涉及到心肌梗塞后的细胞外矩阵重塑.
- MMPs在缺血-再输血诱导的心肌功能障碍中的直接作用尚不清楚.
研究的目的:
- 为了研究MMPs在隔离大鼠心中的缺血-再输液期间的释放和功能影响.
- 评估MMP抑制作为潜在的治疗策略,用于缺血-再输血损伤.
主要方法:
- 隔离, perfused 鼠心受到全球无流动性缺血症,然后再输血.
- 在冠状动脉废水中测量MMPs (pro-MMP-2,MMP-2,75-kDa凝酶).
- 评估心脏机械功能的恢复.
- 使用MMP-2抗体,多西环素和o-phenanthroline的药理干预.
主要成果:
- 在再注射过程中,PromMP-2的释放到冠状动脉废水中显著增加,在第一分钟内达到峰值.
- 增加的亲MMP-2释放与机械功能恢复有负相关性.
- 抑制MMP (多西环素,o-phenanthroline) 和MMP-2抗体改善了功能恢复,而MMP-2则使其恶化.
结论:
- 在再注射过程中,MMP-2的急性释放会导致心脏机械功能障碍.
- 抑制MMP是一种潜在的新型治疗方法,用于缺血-再输液损伤.
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